Article by bcured
DNA poxvirus, the largest virus known, causes molluscum contagiosum. The inner and outer membranes of the virion surround a dumbbell-shaped nucleoid. The genome is a linear duplex DNA with an estimated weight of 120-200 megadaltons. Restriction endonuclease analysis of the molluscum contagiosum virus (MCV) reveals 4 viral subtypes named MCV 1, 2, 3, and 4.All subtypes cause similar clinical symptoms. The most common subtypes, MCV 1 and MCV 2, have genomes of 185 kb and 195 kb. MCV encodes an antioxidant protein, selenoprotein, which functions as a scavenger of reactive oxygen metabolites and protects cells from UV or peroxide damage. The particular role of this protein is not known because the attempt to grow MCV in vitro has not been successful.The epidermis is acanthotic and may measure up to 6 times the normal thickness. Basal cells are slightly larger and more columnar than normal, with dense and granular nuclei. Above the basal keratinocytes are enlarged keratinocytes with a deep purple appearance. The molluscum body is the result of a virally induced cytoplasmic transformation that begins in the lower cells of the epidermis, just above the basal cell layer.Keratinocytes contain multiple Feulgen-positive intracytoplasmic inclusion bodies containing viral particles that can be identified in the cells of stratum spinosum. The viral particles increase in size as they progress up toward the granular layer causing compression of the nucleus to the periphery of the infected keratinocytes. The core of the down-growth of the central stratum corneum of the papules is largely replaced by viral particles.The dermis under the infected lobule of epidermis is normal except for occasional inflammation. Approximately 17% of molluscum contagiosum lesions may have an inflammatory reaction. In HIV-infected patients, acanthosis, hyperkeratosis, and nuclear atypia are also present. In these patients, viral structures may be present up to 1 cm away from clinically observed lesions.Generally, diagnosis is made on clinical grounds based on appearance of the lesions. Identification of characteristic intracytoplasmic inclusion bodies in histologic or cytologic preparations is made by hematoxylin and eosin staining of biopsy sections. Serum antibodies have been measured by complement fixation, tissue culture neutralization, fluorescent antibody, and gel agar diffusion techniques; however, they are not well standardized.Smears from scrapings of lesions stained by Papanicolaou or Wright, Giemsa, or Gram stains reveal inclusion bodies. Antigen of MCV may be identified by fluorescent antibody technique. Electron micrographs of fixed material from papule are taken. Sexually active patients also may have other concomitant venereal diseases such as syphilis and gonorrhea, so their partners also should be examined to prevent reinoculation. Biopsy is performed if diagnosis is uncertain.Other problems to be considered include histiocytoma, nevus (intradermal), and varicella. In addition, when multiple lesions are present, vulvar syringoma and condyloma acuminata should be considered. In patients with AIDS, cutaneous Cryptococcus infection manifesting as a molluscumlike eruption has been reported.AntiMolluscum-Rx is composed of naturally occurring high intensity antiviral extracts which have a lethal effect against the virus upon exposure. Application of this molluscum contagiosum treatment provides maximum and rapid penetration of antiviral agents into cell membranes without damaging healthy skin tissue.As a result, this treatment for molluscum enjoys a well earned reputation for its curative effects. AntiMolluscum-Rx is the most effective among the organic molluscum treatments today as it has very strong and real antiviral properties that destroy the virus. The antiviral pharmacological activity of this molluscum treatment is well documented.Very recent advances in the scientific understanding of medicinal plants suggest a much broader use of natural medicine in the process of eradicating molluscum and infectious viral diseases than science thought possible just ten years ago. The disease occurring anywhere on the body can be successfully eliminated with application of AntiMolluscum-Rx.This molluscum contagiosum treatment is concentrated with naturally occurring monoterpene aldehydes that have tremendous antiviral effects against the molluscum virus, as demonstrated in published scientific studies. To learn more, please go to http://www.naturespharma.org.
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